Japanese anime based on the graphic novel of Project Itoh. This is the first feature of the trilogy made up of Gyakusatsu kikan and Shisha no Teikoku. Set in the near future, the story tells how medical nanotechnology allows the most unlikely goals to be achieved. Ethics has been neglected, so three young girls decide to stand up against this health advance and try to commit suicide. Eventually they will not succeed, but one of them will get into the World Health Organization over the years. Years later she will be reunited with her old friends, with whom she will try to save the planet from a great threat.