Peter Parker (Tom Holland) decides to leave his heroics aside for a few weeks, and goes on a trip through Europe with his friends Ned (Jacob Batalon), MJ (Zendaya) and the rest of his classmates. But summer vacations will take an unexpected turn when Nick Furia (Samuel L. Jackson) appears, who has work for Peter. The Elementals, creatures of sand, stone, water and fire, are creating chaos and destruction throughout the continent. The young Spider-Man must unravel the mystery of these attacks. Alone and with his friends in trouble, in addition to the new appearance of Mysterio (Jake Gyllenhaal), Peter will have to take full responsibility now that Iron Man / Tony Stark is gone.