Eliza Malone D’Amico (Hope Davis) is convinced that her marriage is going well until she casually discovers a love letter from her husband, Louis D’Amico (Stanley Tucci), which leads one to think that he is having an extramarital affair . Eliza decides to hunt and capture her spouse in New York and catch him in fraganti. In advance, and given his degree of concern, he decides to ask his mother for advice. Without knowing very well how, the whole family, including mother, father, sister and brother-in-law, get into a van to accompany Eliza on her New York journey and offer her support when she delivers the letter discovered to Louis.
The Daytrippers was the directorial debut of New York director Greg Mottola, before his most popular Supersalidos and Adventureland.